Seminars in Arthritis and Rheumatism

Objective: The disease burden in rheumatoid arthritis evaluates the physical and psychosocial extra-articular diverse disease manifestations. Methods: MEDLINE searches identified papers published that evaluated systemic complications and psychosocia given to studies with randomized cohorts and large (410 initial search, 118 were selected for inclusion. Results: RA is associated with multiple comorbidities an vascular disease, osteoporosis, interstitial lung disease cognitive dysfunction, reduced work performance, work of life. The etiology of the extra-articular burden may r system alteration associated with RA, metabolic imbalan influence of comorbidities. Strategies that may help to re personalized medicine and the potential introduction of Conclusion: Despite improvements in treating joint dise substantial, encompassing multiple comorbidities and p 72/$ see front matter & 2014 Elsevier Inc. A x.doi.org/10.1016/j.semarthrit.2013.08.004 rted by a grant from Novartis Pharma A sation for their involvement in this project. unding source did not have any involveme n, analysis, and interpretation of published ioScience Communications, New York, NY, of the manuscript with direct guidance by the manuscript for publication was made e from the funding source. esponding author. ail address: [email protected] (M. Cutolo). (RA) extends beyond the joint. This article burden of treated RA and relationships among in English from January 2003 to December 2012 l aspects associated with RA. Preference was 0) sample sizes. Of 378 articles identified in the d psychosocial impairments, including cardio, infection, malignancies, fatigue, depression, disability, and decreased health-related quality eflect the systemic inflammation and immune ces and side effects related to treatment, or the duce the extra-articular disease burden include treatments with new mechanisms of action. ase, the extra-articular burden in RA remains sychosocial impairments. & 2014 Elsevier Inc. All rights reserved.